3型人腺病毒的五聚体基座具有RGD基序。
The penton base of human adenovirus type 3 has the RGD motif.
作者信息
Cuzange A, Chroboczek J, Jacrot B
机构信息
Institut de Biologie Structurale, Grenoble, France.
出版信息
Gene. 1994 Sep 2;146(2):257-9. doi: 10.1016/0378-1119(94)90302-6.
PMID:8076828
Abstract
The gene encoding the penton base of human adenovirus (Ad) type 3 has been sequenced. The resulting amino-acid sequence has an Arg-Gly-Asp (RGD) motif located near its middle in a hydrophilic region. The same motif is found in serotypes 2, 5 and 12. This sequence was found [Wickham et al., Cell 73 (1993) 309-319] to be involved in the internalisation of Ad2 through an interaction with some specific integrins.
摘要
已对人3型腺病毒（Ad）五邻体基底的编码基因进行了测序。所得氨基酸序列在其亲水区中部附近有一个精氨酸-甘氨酸-天冬氨酸（RGD）基序。在2型、5型和12型血清型中也发现了相同的基序。已发现该序列[Wickham等人，《细胞》73（1993年）309 - 319]通过与某些特定整合素相互作用参与Ad2的内化过程。
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