人5型腺病毒五邻体基座基因核苷酸序列的测定

Determination of the nucleotide sequence for the penton-base gene of human adenovirus type 5.

作者信息

Neumann R, Chroboczek J, Jacrot B

机构信息

European Molecular Biology Laboratory, Grenoble Outstation, France.

出版信息

Gene. 1988 Sep 15;69(1):153-7. doi: 10.1016/0378-1119(88)90389-7.

DOI:10.1016/0378-1119(88)90389-7

PMID:3224820

Abstract

The major structural proteins of adenovirus (Ad), which form the external capsid, are hexon, penton base and fiber. The primary structure of the Ad5 penton base has been deduced from the nucleotide sequence of the corresponding gene. It has 98.6% homology with the sequence of the analogous protein from Ad2. This result is in contrast with the significantly lower homology found for the two other major structural proteins, the hexon and the fiber.

摘要

构成腺病毒（Ad）外部衣壳的主要结构蛋白是六邻体、五邻体基座和纤维。Ad5五邻体基座的一级结构已根据相应基因的核苷酸序列推导得出。它与Ad2中类似蛋白的序列具有98.6%的同源性。这一结果与另外两种主要结构蛋白六邻体和纤维的同源性明显较低形成对比。