Mane S V, Gharpure V P, Merchant R H
Division of Obstetrics, Nowrosjee Wadia Maternity Hospital, Bombay.
Indian Pediatr. 1993 Dec;30(12):1407-11.
Between January 1991 and August 1992, 62 singleton pregnancies with heart disease were managed at the Wadia Maternity Hospital, Bombay. In 51 (82.3%), the heart disease was of rheumatic origin, while in 11 (17.7%), the disease was nonrheumatic. Thirteen cases of rheumatic disease (25.4%) were graded as Class III or IV, as per New York Heart Association (NYHA) classification. Six cases with rheumatic disease had closed mitral commisurotomy done, while none had a prosthetic heart valve. There was no maternal mortality. The average birth weight of neonates born to mothers with Class III or IV rheumatic heart disease was significantly lower (p < 0.05) than the average noted in singleton, normal, uncomplicated, non high risk pregnancies, during this period. There was also a significant difference (p < 0.05) in birth weight between infants born to mothers with NYHA Class I or II and Class III or IV symptoms. No infant had a congenital heart disease. Our findings suggest that though the presence of maternal heart disease did not affect the perinatal outcome, all infants born to mothers with NYHA Class III or IV had intrauterine growth retardation.
1991年1月至1992年8月期间，孟买瓦迪亚妇产医院对62例单胎妊娠合并心脏病患者进行了治疗。其中51例（82.3%）心脏病源于风湿，11例（17.7%）为非风湿性疾病。根据纽约心脏协会（NYHA）分类，13例风湿性疾病患者（25.4%）被列为III级或IV级。6例风湿性疾病患者接受了二尖瓣闭式分离术，无人安装人工心脏瓣膜。无孕产妇死亡情况。患有III级或IV级风湿性心脏病的母亲所生新生儿的平均出生体重显著低于（p < 0.05）该时期单胎、正常、无并发症、非高危妊娠的平均出生体重。NYHA I级或II级症状母亲所生婴儿与III级或IV级症状母亲所生婴儿的出生体重也存在显著差异（p < 0.05）。无婴儿患有先天性心脏病。我们的研究结果表明，尽管母亲患有心脏病并不影响围产期结局，但NYHA III级或IV级母亲所生的所有婴儿均有宫内生长受限情况。
