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利用人源化严重联合免疫缺陷小鼠模型评估11型人乳头瘤病毒的温度敏感性

Evaluation of temperature sensitivity of human papillomavirus type 11 by using the human xenograft severe combined immunodeficiency mouse model.

作者信息

Bonnez W, Rose R C, Borkhuis C, Da Rin C, Reichman R C

机构信息

Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.

出版信息

J Clin Microbiol. 1994 Jun;32(6):1575-7. doi: 10.1128/jcm.32.6.1575-1577.1994.

Abstract

The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56 degrees C but lower than 72 degrees C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100 degrees C was necessary to completely inactivate HPV type 11 genome expression.

摘要

通过使用人异种移植严重联合免疫缺陷小鼠模型评估了11型人乳头瘤病毒的温度敏感性。在高于56℃但低于72℃的温度下将病毒孵育1小时足以抑制病毒诱导的受感染人体组织生长。然而,需要100℃才能完全灭活11型人乳头瘤病毒基因组表达。

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