Plouffe J F, Moore S K, Davis R, Facklam R R
Department of Internal Medicine, Ohio State University, Columbus 43210.
J Clin Microbiol. 1994 Jun;32(6):1606-7. doi: 10.1128/jcm.32.6.1606-1607.1994.
Isolates of Streptococcus pneumoniae in cultures of blood from 258 adults seen in 10 Franklin County, Ohio, hospitals from 1991 and 1992 were serotyped. Most strains (230 [89.2%]) belonged to serotypes that are included in the current pneumococcal vaccine. An additional 16 isolates (6.2%) were immunologically related to strains with serotypes that are included in the vaccine. Only 12 isolates (4.6%) were not covered by the vaccine. The rate of mortality from pneumococcal bacteremia in adults remains high (20%). While recent studies have documented the efficacy of the pneumococcal vaccine for preventing pneumococcal bacteremia (56 to 70%), use of the pneumococcal vaccine in susceptible patients by physicians remains low (19% in Franklin County). Additional efforts need to be expended to increase the use of the pneumococcal vaccine.
对1991年和1992年在俄亥俄州富兰克林县10家医院就诊的258名成年人血液培养物中的肺炎链球菌分离株进行了血清分型。大多数菌株（230株[89.2%]）属于目前肺炎球菌疫苗所包含的血清型。另外16株分离株（6.2%）与疫苗所包含血清型的菌株存在免疫相关性。只有12株分离株（4.6%）不在疫苗覆盖范围内。成人肺炎球菌菌血症的死亡率仍然很高（20%）。虽然最近的研究证明了肺炎球菌疫苗预防肺炎球菌菌血症的有效性（56%至70%），但医生在易感患者中使用肺炎球菌疫苗的比例仍然很低（富兰克林县为19%）。需要付出更多努力来提高肺炎球菌疫苗的使用。
