寻常型天疱疮患者家庭成员自身免疫性疾病的患病率
Prevalence of autoimmune diseases in the family members of patients with pemphigus vulgaris.
作者信息
Firooz A, Mazhar A, Ahmed A R
机构信息
Department of Dermatology, Boston University School of Medicine, MA 02118.
出版信息
J Am Acad Dermatol. 1994 Sep;31(3 Pt 1):434-7. doi: 10.1016/s0190-9622(94)70206-3.
BACKGROUND
Several studies show that the family members of patients with autoimmune diseases are more susceptible to the development of the same or, more frequently, other autoimmune diseases. Although an association between pemphigus vulgaris (PV) and other autoimmune diseases has been reported, the presence of autoimmune diseases in the family members of patients with PV has not been studied.
OBJECTIVE
The purpose of this study was to determine whether first-degree relatives of patients with PV are more susceptible to the development of autoimmune diseases.
METHODS
A case-control study was done. A total of 830 first-degree relatives of 60 white patients with PV were compared with 890 relatives of 60 age-, race-, and sex-matched random controls. Both groups of relatives were screened for the presence of 16 autoimmune diseases.
RESULTS
There was a highly significant increase in the prevalence of autoimmune diseases in the first-degree family members of PV patients, compared with controls.
CONCLUSION
There is an increased susceptibility to the development of autoimmune diseases in the family members of patients with PV.
背景
多项研究表明，自身免疫性疾病患者的家庭成员更易患相同的自身免疫性疾病，或者更常见的是，患其他自身免疫性疾病。尽管已有报告寻常型天疱疮（PV）与其他自身免疫性疾病之间存在关联，但PV患者家庭成员中自身免疫性疾病的存在情况尚未得到研究。
目的
本研究的目的是确定PV患者的一级亲属是否更易患自身免疫性疾病。
方法
进行了一项病例对照研究。将60例白人PV患者的830名一级亲属与60名年龄、种族和性别匹配的随机对照者的890名亲属进行比较。对两组亲属进行了16种自身免疫性疾病的筛查。
结果
与对照组相比，PV患者一级家庭成员中自身免疫性疾病的患病率显著增加。
结论
PV患者的家庭成员患自身免疫性疾病的易感性增加。
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