Katz J, Langevitz P, Shemer J, Barak S, Livneh A
Department of Dentistry, Sheba Medical Center, Tel-Hashomer, Israel.
J Am Acad Dermatol. 1994 Sep;31(3 Pt 1):459-61. doi: 10.1016/s0190-9622(94)70211-x.
Recurrent aphthous stomatitis (RAS) is a common disorder with hitherto unsatisfactory drug therapy.
Our purpose was to evaluate the prophylactic effect of colchicine in the treatment of RAS.
An open, prospective, 4-month study was conducted in 20 patients with RAS who served as their own controls. During the first 2 months of the study no medications were given and in the last 2 months colchicine, 1.5 mg/day, was prescribed.
The mean number of aphthae per week and the subjective daily pain scores were reduced by 71% and 77%, respectively, during colchicine treatment as compared with the previous period (p < 0.001 for both). No serious side effects of colchicine were noted.
These findings suggest a role for continuous colchicine therapy in the prevention of RAS.
复发性阿弗他口炎（RAS）是一种常见疾病，目前药物治疗效果不尽人意。
我们的目的是评估秋水仙碱在治疗RAS中的预防作用。
对20例RAS患者进行了一项为期4个月的开放性前瞻性研究，患者自身作为对照。研究的前2个月未给予任何药物，后2个月给予秋水仙碱，剂量为1.5毫克/天。
与前一时期相比，秋水仙碱治疗期间每周口疮的平均数量和主观每日疼痛评分分别降低了71%和77%（两者p均<0.001）。未观察到秋水仙碱的严重副作用。
这些发现表明持续秋水仙碱治疗在预防RAS中具有一定作用。
