Bickers D R
Skin Diseases Research Center, Case Western Reserve University School of Medicine.
J Am Acad Dermatol. 1994 Sep;31(3 Pt 2):S87-90. doi: 10.1016/s0190-9622(08)81276-5.
Combination drug therapy is widely used for the management of many common medical conditions. The concurrent use of more than one drug can significantly alter the therapeutic and side-effect profile of each individual agent. Such drug-drug interactions are generally classified either as pharmacokinetic or pharmacodynamic. Oral agents used for the management of superficial fungal infections can have both types of interactions. This article describes common drug-drug interactions observed with amphotericin B, flucytosine, griseofulvin, ketoconazole, fluconazole, and itraconazole.
联合药物疗法广泛用于多种常见病症的治疗。同时使用一种以上药物可显著改变每种药物的治疗效果和副作用情况。此类药物相互作用通常分为药代动力学或药效学相互作用。用于治疗浅表真菌感染的口服药物可能会出现这两种相互作用。本文介绍了两性霉素B、氟胞嘧啶、灰黄霉素、酮康唑、氟康唑和伊曲康唑常见的药物相互作用。
