Bryan J P, Tsarev S A, Iqbal M, Ticehurst J, Emerson S, Ahmed A, Duncan J, Rafiqui A R, Malik I A, Purcell R H
Department of Preventive Medicine and Biometrics, Uniformed Services, University of the Health Sciences, Bethesda, MD 20814-4799.
J Infect Dis. 1994 Sep;170(3):517-21. doi: 10.1093/infdis/170.3.517.
IgM and IgG anti-hepatitis E virus (HEV) patterns were determined in sera collected during a hepatitis outbreak in Pakistan. HEV infection was detected serologically in 122 patients. IgM anti-HEV was detected in specimens collected up to 2 weeks before and 5-7 weeks after hospitalization in 91% and 100%, respectively, of 122 HEV-infected patients. IgG followed a similar pattern. Peak antibody titers appeared 2-4 weeks after hospitalization. At 20 months after hospitalization, IgM anti-HEV was not detected in any of 33 patients; IgG was found in all. IgG anti-HEV appeared to be protective in contracts of patients. This study confirms HEV as the cause of the outbreak, quantifies IgM and IgG anti-HEV responses, provides evidence that IgG anti-HEV protects against hepatitis E, and demonstrates that IgG anti-HEV persists, but at diminished titer, after infection. Hepatitis E in young adults is the result of primary infection with HEV and, if reinfection occurs, it does not commonly cause serious illness.
在巴基斯坦一次肝炎暴发期间收集的血清中检测了IgM和IgG抗戊型肝炎病毒（HEV）模式。在122例患者中通过血清学检测到HEV感染。在122例HEV感染患者中，分别有91%和100%的患者在住院前2周内及住院后5 - 7周采集的标本中检测到IgM抗HEV。IgG呈现类似模式。抗体滴度峰值出现在住院后2 - 4周。住院20个月后，33例患者中无一例检测到IgM抗HEV；所有患者均检测到IgG。IgG抗HEV似乎对患者有保护作用。本研究证实HEV是此次暴发的病因，量化了IgM和IgG抗HEV反应，提供了IgG抗HEV预防戊型肝炎的证据，并表明IgG抗HEV在感染后持续存在，但滴度降低。年轻人的戊型肝炎是HEV初次感染的结果，并且如果再次感染发生，通常不会导致严重疾病。
