Iida H, Taji H, Iida M, Suzuki R, Sugihara T, Minami S, Kodera Y, Yamamoto K, Seto M, Ueda R
Department of Internal Medicine, Japan Red Cross Nagoya First Hospital.
Rinsho Ketsueki. 1994 Jun;35(6):569-75.
The 11q23 chromosomal abnormality is frequently observed in infantile leukemia and secondary leukemia, and the translocation associated gene in infantile leukemia is called mixed-lineage leukemia (MLL) gene. A 50-year-old man was admitted because of left axillary lymphadenopathy and IBL like T cell lymphoma was diagnosed by lymph node biopsy. The patient responded to the LSG-9 protocol with complete remission. After 10 months he was readmitted because of fever and was diagnosed acute myeloblastic leukemia by bone marrow aspiration. Chromosome analysis revealed 11q23 abnormality, suggesting that the leukemia was induced by etoposide treatment. Southern blot analysis demonstrated DNA rearrangement in the MLL gene at 11q23. It was suggested that the breakpoint region of the MLL gene in secondary leukemia is the same as that of infantile leukemia.
11q23染色体异常在婴儿白血病和继发性白血病中经常可见，婴儿白血病中的易位相关基因被称为混合谱系白血病（MLL）基因。一名50岁男性因左腋窝淋巴结病入院，经淋巴结活检诊断为间变性大细胞淋巴瘤（IBL）样T细胞淋巴瘤。该患者对LSG-9方案有反应，达到完全缓解。10个月后，他因发热再次入院，经骨髓穿刺诊断为急性髓细胞白血病。染色体分析显示11q23异常，提示白血病是由依托泊苷治疗诱发的。Southern印迹分析表明11q23处的MLL基因发生了DNA重排。提示继发性白血病中MLL基因的断裂点区域与婴儿白血病相同。
