Kaufman E, Solomon V, Rozen L, Peltz R
Hospital Oral Medicine Service, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.
Oral Surg Oral Med Oral Pathol. 1994 Jul;78(1):17-21. doi: 10.1016/0030-4220(94)90111-2.
Four lidocaine solutions that differed in concentration or vasoconstrictor composition were compared for efficacy of pulpal anesthesia. These drugs were injected in a double-blind manner with the use of an intraligamentary syringe to the periodontal ligament of maxillary lateral incisors. These teeth were subjected to electric pulp test stimulation that yielded absolute sensation threshold values. It was found that there was no dose response relationship between the local anesthetic concentration and the efficacy of pulpal anesthesia. Lidocaine 2% with vasopressin 25 IU% and noradrenaline bitartrate produced a noticeably shorter duration of pulpal anesthesia in comparison with the other three drugs. The results indicated that the nature of vasoconstrictors when added to the local anesthetic can affect the efficacy of pulpal anesthesia using the intraligamentary model.
比较了四种浓度或血管收缩剂成分不同的利多卡因溶液用于牙髓麻醉的效果。使用牙周膜注射器以双盲方式将这些药物注射到上颌侧切牙的牙周膜中。对这些牙齿进行电牙髓测试刺激，得出绝对感觉阈值。结果发现，局部麻醉剂浓度与牙髓麻醉效果之间不存在剂量反应关系。与其他三种药物相比，含25国际单位%血管加压素和重酒石酸去甲肾上腺素的2%利多卡因产生的牙髓麻醉持续时间明显较短。结果表明，在局部麻醉剂中添加血管收缩剂的性质会影响使用牙周膜模型进行牙髓麻醉的效果。
