Lawaty Ingrid, Drum Melissa, Reader Al, Nusstein John
Private Practice in Endodontics, Santa Barbara, California, USA.
Anesth Prog. 2010 Winter;57(4):139-44. doi: 10.2344/0003-3006-57.4.139.
The purpose of this prospective, randomized, double-blind crossover study was to compare the anesthetic efficacy of 2% mepivacaine with 1 : 20,000 levonordefrin versus 2% lidocaine with 1 : 100,000 epinephrine in maxillary central incisors and first molars. Sixty subjects randomly received, in a double-blind manner, maxillary central incisor and first molar infiltrations of 1.8 mL of 2% mepivacaine with 1 : 20,000 levonordefrin and 1.8 mL of 2% lidocaine with 1 : 100,000 epinephrine at 2 separate appointments spaced at least 1 week apart. The teeth were electric pulp tested in 2-minute cycles for a total of 60 minutes. Anesthetic success (obtaining 2 consecutive 80 readings with the electric pulp tester within 10 minutes) was not significantly different between 2% mepivacaine with 1 : 20,000 levonordefrin and 2% lidocaine with 1 : 100,000 epinephrine for the central incisor and first molar. However, neither anesthetic agent provided an hour of pulpal anesthesia.
这项前瞻性、随机、双盲交叉研究的目的是比较2%甲哌卡因与1∶20000左旋去甲肾上腺素组合和2%利多卡因与1∶100000肾上腺素组合在上颌中切牙和第一磨牙的麻醉效果。60名受试者以双盲方式，在两次至少间隔1周的单独就诊中，分别接受上颌中切牙和第一磨牙的浸润麻醉，一次注射1.8 mL含1∶20000左旋去甲肾上腺素的2%甲哌卡因，另一次注射1.8 mL含1∶100000肾上腺素的2%利多卡因。用牙髓电活力测试仪以2分钟为一个周期对牙齿进行测试，共测试60分钟。对于中切牙和第一磨牙，含1∶20000左旋去甲肾上腺素的2%甲哌卡因与含1∶100000肾上腺素的2%利多卡因在麻醉成功率（在10分钟内用牙髓电活力测试仪连续两次读数达到80）方面无显著差异。然而，两种麻醉剂均未提供1小时的牙髓麻醉。
