Hayashi H, Kumazaki T, Asano G
Department of Radiology, Nippon Medical School.
Radiat Med. 1994 Mar-Apr;12(2):47-52.
An experimental study of changes in the lung induced by the intravenous administration of iodinated contrast media was carried out using rats. The increase in the relative lung weight and histological findings, especially pulmonary edema, were evaluated in control, physiological saline, diatrizoate sodium meglumine, iohexol, and ioxaglate groups. The relative lung weight increased significantly in all contrast media groups. Proximal and distal perivascular edema were confirmed microscopically. No statistically significant differences among the contrast media were noted in the increase in relative lung weight or in the degree of perivascular edema. There was a close correlation between the increase in relative lung weight and the degree of perivascular edema. These physiological and histological changes in the lung occurred irrespective of the osmolality of the contrast materials. We considered these phenomena to be induced by non-osmolality related toxicity of the contrast medium.
利用大鼠进行了一项关于静脉注射碘化造影剂后肺部变化的实验研究。在对照组、生理盐水组、泛影葡胺钠组、碘海醇组和碘克沙醇组中评估了相对肺重量的增加和组织学结果，尤其是肺水肿情况。所有造影剂组的相对肺重量均显著增加。在显微镜下证实存在近端和远端血管周围水肿。在相对肺重量增加或血管周围水肿程度方面，各造影剂之间未发现统计学上的显著差异。相对肺重量的增加与血管周围水肿程度之间存在密切相关性。肺部的这些生理和组织学变化与造影剂的渗透压无关。我们认为这些现象是由造影剂的非渗透压相关毒性引起的。
