Inoue H, Miyazono N, Miyake S, Nishida H, Kanetsuki I, Hori A, Mukai H, Ueno K, Nakajo M
Department of Radiology, Faculty of Medicine, Kagoshima University, Japan.
Radiat Med. 1994 Mar-Apr;12(2):53-8.
The distribution of iodized oil (Lipiodol) after its injection in hepatocellular carcinoma (HCC) was evaluated by dynamic computed tomography (CT) in 10 patients. Following the injection of Lipiodol into the hepatic artery, two patterns were observed. In type I (4/10 tumors) Lipiodol retention began at the tumor periphery and then spread contiguously towards the central portion. In type II (6/10 tumors), the accumulation began at the periphery, but then skipped directly to the central portion of the tumor. Hypervascular tumors were predominantly type I, and avascular or hypovascular tumors were all type II. This difference in Lipiodol kinetics suggests that lipid-based intra-arterial (i.a.) chemoembolization should precede the i.a. infusion of water-soluble chemotherapeutic agents or injection of solid embolic materials in hypervascular tumors.
通过动态计算机断层扫描（CT）对10例肝细胞癌（HCC）患者注射碘化油（碘油）后的分布情况进行了评估。在将碘油注入肝动脉后，观察到两种模式。在I型（10个肿瘤中的4个）中，碘油滞留从肿瘤周边开始，然后向中心部分连续扩散。在II型（10个肿瘤中的6个）中，积聚从周边开始，但随后直接跳跃至肿瘤中心部分。高血供肿瘤主要为I型，无血供或低血供肿瘤均为II型。碘油动力学的这种差异表明，在高血供肿瘤中，基于脂质的动脉内（i.a.）化疗栓塞应先于水溶性化疗药物的动脉内输注或固体栓塞材料的注射。
