Krogh H V, Linnet A, Knudsen P B
Nord Vet Med. 1975 May;27(5):285-95.
The effect on canine otitis externa of a topical preparation composed of Fucidin, Framycetin, Nystatin, and Prednisolone was evaluated in a clinical trial comprising 235 dog ears. Cases caused by parasites or foreign bodies and cases requiring systemic therapy were excluded. Swabs from these and an additional 434 affected ears were examined bacteriologically and the sensitivity to antibiotics of the bacteria isolated determined. The infection most frequently diagnosed was staphylococci plus yeasts (29 % of total material) followed by pure yeast-infections (19 %) and pure staphylococcus infections (16 %). Pseudomonas aeruginosa and/or Proteus mirabilis were found in 7 % of the ears, while no organisms could be isolated from 22 %. Sensitivity tests showed a satisfactory in vitro effect of Neomycin (Framycetin) on most of the bacteria commonly isolated, and a very good effect of Fucidin on the staphylococci. Approximately 91 % of the ears treated were clinically cured or improved very considerably; the relation between clinical response and type of infection is shown diagrammatically in Fig. 1. It was confirmed that infections with Ps. aeruginosa represent a special problem; the results of post-treatment sensitivity tests seem to suggest, however, that a longer or more intense course of treatment than the one used in the trial (two weeks) would provide the answer to this.
在一项包含235只犬耳的临床试验中，评估了由夫西地酸、新霉素、制霉菌素和泼尼松龙组成的外用制剂对犬外耳炎的疗效。排除由寄生虫或异物引起的病例以及需要全身治疗的病例。对这些耳朵以及另外434只患耳的拭子进行细菌学检查，并确定分离出的细菌对抗生素的敏感性。最常诊断出的感染是葡萄球菌加酵母菌（占总样本的29%），其次是单纯酵母菌感染（19%）和单纯葡萄球菌感染（16%）。7%的耳朵中发现了铜绿假单胞菌和/或奇异变形杆菌，而22%的耳朵未分离出任何微生物。敏感性测试表明，新霉素（新霉素）对大多数常见分离细菌具有令人满意的体外效果，夫西地酸对葡萄球菌具有非常好的效果。大约91%接受治疗的耳朵在临床上治愈或有非常明显的改善；临床反应与感染类型之间的关系如图1所示。证实铜绿假单胞菌感染是一个特殊问题；然而，治疗后敏感性测试结果似乎表明，比试验中使用的疗程（两周）更长或更强化的疗程将为解决这个问题提供答案。
