奥美拉唑处理的鸡甲状旁腺的生长情况

Growth of the parathyroid glands in omeprazole-treated chickens.

作者信息

Gagnemo-Persson R, Håkanson R, Sundler F, Persson P

机构信息

Dept. of Pharmacology, University of Lund, Sweden.

出版信息

Scand J Gastroenterol. 1994 Jun;29(6):493-7. doi: 10.3109/00365529409092460.

DOI:10.3109/00365529409092460

PMID:8079105

Abstract

BACKGROUND

Omeprazole, a long-acting inhibitor of gastric acid secretion, is able to increase the circulating concentrations of gastrin. Daily treatment with high doses of omeprazole cause sustained hypergastrinemia. Long-standing hypergastrinemia can be expected to exert numerous effects in the body. For instance, gastrin has been proposed to promote growth in the digestive tract and pancreas. The present study is concerned with the effect of omeprazole on parathyroid glands in the chicken.

METHODS

Chickens were treated with omeprazole (400 mumol/kg/day) in methylcellulose (2.5 ml/kg) for 5 or 10 weeks. Controls received vehicle. Blood calcium and serum gastrin concentrations were studied. The weight gain of the animals and of various organs (proventriculus, antrum, thyroids, parathyroids, ultimobranchial glands, and femur) were determined. The DNA content and the size of the parathyroid chief cells were also determined.

RESULTS

Omeprazole reduced the body weight gain while greatly increasing the weight of the proventriculus and the parathyroid glands. The weight and density of the femur were reduced. The circulating concentrations of calcium were unaffected. The DNA content of the parathyroid glands was increased, and morphometric analysis of the parathyroid chief cells showed an increased cell size. Thus, the increased parathyroid gland weight seems to reflect both hypertrophy and hyperplasia. There was a slight increase in the weight of the ultimobranchial glands (expressed per kilogram body weight). The weight of the thyroids was unaffected (expressed in relation to body weight).

CONCLUSIONS

The results indicate that omeprazole treatment in chickens leads not only to trophic effects in the acid-producing gastric mucosa (probably because of the ensuing hypergastrinemia), as reported earlier, but also to growth of the parathyroid glands (both hypertrophy and hyperplasia) and to bone loss without affecting blood calcium values. The mechanism behind these effects remains unknown.

摘要

背景

奥美拉唑是一种长效胃酸分泌抑制剂，能够提高胃泌素的循环浓度。每日高剂量使用奥美拉唑会导致持续性高胃泌素血症。长期的高胃泌素血症预计会在体内产生多种影响。例如，有人提出胃泌素可促进消化道和胰腺的生长。本研究关注奥美拉唑对鸡甲状旁腺的影响。

方法

将鸡用溶于甲基纤维素（2.5毫升/千克）的奥美拉唑（400微摩尔/千克/天）处理5或10周。对照组给予赋形剂。研究血钙和血清胃泌素浓度。测定动物及各种器官（腺胃、胃窦、甲状腺、甲状旁腺、后鳃体和股骨）的体重增加情况。还测定甲状旁腺主细胞的DNA含量和大小。

结果

奥美拉唑降低了体重增加，同时极大地增加了腺胃和甲状旁腺的重量。股骨的重量和密度降低。血钙的循环浓度未受影响。甲状旁腺的DNA含量增加，对甲状旁腺主细胞的形态计量分析显示细胞大小增加。因此，甲状旁腺重量增加似乎反映了肥大和增生。后鳃体的重量略有增加（以每千克体重表示）。甲状腺的重量未受影响（相对于体重表示）。