Håkanson R, Axelson J, Ekman R, Sundler F
Department of Pharmacology, University of Lund, Sweden.
Regul Pept. 1988 Oct;23(1):105-15. doi: 10.1016/0167-0115(88)90426-0.
Treatment of chickens, hamsters and guinea-pigs with the long-acting anti-secretagogue omeprazole resulted in elevated levels of serum gastrin. The chickens received 400 mumol/kg by i.m. injection once daily, the hamsters and guinea-pigs received the same dose by the oral route once daily. In all 3 species omeprazole raised the intragastric pH to 4, measured 12-14 h after the administration of the drug. After 10 weeks of treatment, trophic changes were observed in the stomach of hamster and guinea pig and in the proventriculus of chicken. The trophic changes were manifested in a greatly increased stomach weight and gastric mucosal mass. There were no trophic effects outside the stomach (or proventriculus). The results are in agreement with previous observations in the rat and support the view that long-lasting sustained hypergastrinaemia causes trophic changes in the stomach but not in the pancreas or in the intestines.
用长效抗分泌剂奥美拉唑治疗鸡、仓鼠和豚鼠后，血清胃泌素水平升高。鸡每天一次肌肉注射400 μmol/kg，仓鼠和豚鼠每天一次经口给予相同剂量。在所有这3个物种中，给药12 - 14小时后测量发现，奥美拉唑使胃内pH值升至4。治疗10周后，在仓鼠和豚鼠的胃以及鸡的腺胃中观察到了营养性变化。营养性变化表现为胃重量和胃黏膜质量大幅增加。胃（或腺胃）以外没有营养性影响。这些结果与先前在大鼠中的观察结果一致，并支持这样一种观点，即长期持续的高胃泌素血症会导致胃的营养性变化，但不会导致胰腺或肠道的营养性变化。
