Steenfos H H
Department of Plastic Surgery, Herlev University Hospital, Denmark.
Scand J Plast Reconstr Surg Hand Surg. 1994 Jun;28(2):95-105. doi: 10.3109/02844319409071186.
This paper is based on the thesis Growth Factors and Formation of Granulation Tissue, University of Göteborg, 1992. For the last decade, it has been acknowledged that growth factors are essential for regulating the cellular events involved in the formation of granulation tissue and in wound healing. Recently, clinical trials were initiated to study the wound healing effect of applying growth factors and growth hormone to human wounds. However, in order to apply growth factors in these trials in an intelligent and effective manner, it is important to understand their physiology and their role in wound healing. This review paper is about the growth factors: IGF-I, IGF-II, PDGF, bFGF, TGF-beta, EGF, TGF-alpha, TNF-alpha, SF-HGF and Growth Hormone and their role and effect in soft tissue wound healing in animals and humans.
本文基于1992年于哥德堡大学发表的论文《生长因子与肉芽组织的形成》。在过去十年中，人们已经认识到生长因子对于调节参与肉芽组织形成和伤口愈合的细胞事件至关重要。最近，已启动临床试验以研究将生长因子和生长激素应用于人类伤口的愈合效果。然而，为了在这些试验中明智且有效地应用生长因子，了解它们的生理学及其在伤口愈合中的作用很重要。这篇综述文章是关于胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子-II（IGF-II）、血小板衍生生长因子（PDGF）、碱性成纤维细胞生长因子（bFGF）、转化生长因子-β（TGF-β）、表皮生长因子（EGF）、转化生长因子-α（TGF-α）、肿瘤坏死因子-α（TNF-α）、肝细胞生长因子（SF-HGF）和生长激素，以及它们在动物和人类软组织伤口愈合中的作用和效果。
