• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

促进大鼠皮肤切除伤口愈合：强调其胶原增强、抗氧化和抗炎活性。

Promotes Healing of Excised Wounds in Rat Skin: Emphasis on Its Collagen-Enhancing, Antioxidant, and Anti-Inflammatory Activities.

机构信息

Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, P.O. Box 80260, Saudi Arabia.

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, P.O. Box 61511, Egypt.

出版信息

Oxid Med Cell Longev. 2021 Jan 26;2021:8891445. doi: 10.1155/2021/8891445. eCollection 2021.

DOI:10.1155/2021/8891445
PMID:33574987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7857909/
Abstract

Steud () belongs to the family Asteraceae. It has several uses in folk medicine in the Arabian Peninsula. The current study aimed at evaluating the wound healing properties of the extract in rats. Primarily, successfully accelerated cell migration and it also showed no signs of dermal toxicity. Topical application of extract (5% or 20%) expedited healing of excised skin in rats. Histological examinations indicated that shortened epithelization period, stimulated fibroblast activity, and increased collagen deposition in wound tissues. The plant extract exerted antioxidant activity as evidenced by inhibition of GSH depletion and MDA accumulation and enhanced mRNA expression of Sod1 in wound tissues collected at the end of the experiment. Further, inhibited the rise of TNF- and IL-1 in the skin wound region. The anti-inflammatory was confirmed by the observed down regulation of Ptgs2, Nos2, IL-6, and NF-B mRNA expression. In addition, the extract enhanced the expression of TGF-1 and HIF-1 in wounded skin tissues as indicated immunohistochemically. Conclusively, expedites excision wound healing in rats. Collagen-enhancing, anti-inflammatory, and antioxidant properties mediate the observed wound healing activity. These findings might contribute to our understanding of the ethnobotanical use of in wounds.

摘要

Steud（）属于菊科。它在阿拉伯半岛的民间医学中有多种用途。本研究旨在评估 的提取物在大鼠中的伤口愈合特性。 提取物（5%或 20%）能成功促进细胞迁移，且无皮肤毒性迹象。 提取物的局部应用（5%或 20%）加速了大鼠切除皮肤的愈合。组织学检查表明， 缩短了上皮化期，刺激了成纤维细胞活性，并增加了伤口组织中的胶原蛋白沉积。植物提取物表现出抗氧化活性，这表现在抑制 GSH 耗竭和 MDA 积累以及增加实验结束时收集的伤口组织中 Sod1 的 mRNA 表达。此外， 抑制了 TNF-和 IL-1 在皮肤伤口区域的增加。通过观察到 Ptgs2、Nos2、IL-6 和 NF-B mRNA 表达的下调，证实了抗炎作用。此外，提取物增强了 TGF-1 和 HIF-1 在受伤皮肤组织中的表达，如免疫组化所示。总之， 加速了大鼠的切伤愈合。增强胶原蛋白、抗炎和抗氧化特性介导了观察到的伤口愈合活性。这些发现可能有助于我们理解 在伤口中的民族植物学用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/02bce3ccd0e0/OMCL2021-8891445.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/d8e0b9049a4f/OMCL2021-8891445.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/aa3a3a108c68/OMCL2021-8891445.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/638add540037/OMCL2021-8891445.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/6a6800085d41/OMCL2021-8891445.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/8fc5380a6266/OMCL2021-8891445.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/ea815055763b/OMCL2021-8891445.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/9af2076c1b0d/OMCL2021-8891445.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/02bce3ccd0e0/OMCL2021-8891445.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/d8e0b9049a4f/OMCL2021-8891445.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/aa3a3a108c68/OMCL2021-8891445.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/638add540037/OMCL2021-8891445.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/6a6800085d41/OMCL2021-8891445.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/8fc5380a6266/OMCL2021-8891445.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/ea815055763b/OMCL2021-8891445.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/9af2076c1b0d/OMCL2021-8891445.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/7857909/02bce3ccd0e0/OMCL2021-8891445.008.jpg

相似文献

1
Promotes Healing of Excised Wounds in Rat Skin: Emphasis on Its Collagen-Enhancing, Antioxidant, and Anti-Inflammatory Activities.促进大鼠皮肤切除伤口愈合：强调其胶原增强、抗氧化和抗炎活性。
Oxid Med Cell Longev. 2021 Jan 26;2021:8891445. doi: 10.1155/2021/8891445. eCollection 2021.
2
Euryops arabicus displays anti-inflammatory activities in experimental models.阿拉伯茶显示出在实验模型中具有抗炎活性。
J Ethnopharmacol. 2020 Jan 30;247:112278. doi: 10.1016/j.jep.2019.112278. Epub 2019 Oct 4.
3
The effects of Anchusa azurea methanolic extract on burn wound healing: Histological, antioxidant, and anti-inflammatory evaluation.紫花野芝麻甲醇提取物对烧伤创面愈合的影响：组织学、抗氧化和抗炎评价。
Burns. 2024 Sep;50(7):1812-1822. doi: 10.1016/j.burns.2024.05.001. Epub 2024 May 9.
4
Wound healing potential of licorice extract in rat model: Antioxidants, histopathological, immunohistochemical and gene expression evidences.甘草提取物在大鼠模型中的伤口愈合潜力：抗氧化剂、组织病理学、免疫组织化学和基因表达证据。
Biomed Pharmacother. 2021 Nov;143:112151. doi: 10.1016/j.biopha.2021.112151. Epub 2021 Sep 8.
5
Wound-healing potential of the fruit extract of Phaleria macrocarpa.大果木鳖果提取物的伤口愈合潜力。
Bosn J Basic Med Sci. 2015 May 12;15(2):25-30. doi: 10.17305/bjbms.2015.39.
6
Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats.胆红素通过调节细胞因子、生长因子和血管生成来改善糖尿病大鼠的皮肤伤口愈合过程。
Int Immunopharmacol. 2016 Jan;30:137-149. doi: 10.1016/j.intimp.2015.11.037. Epub 2015 Dec 8.
7
Wound Healing Activity of (Benth.) S. Moore. Leaf Hydroethanolic Extract.（Benth.）S. Moore 叶的水醇提取物的创伤愈合活性。
Oxid Med Cell Longev. 2020 Aug 22;2020:2483187. doi: 10.1155/2020/2483187. eCollection 2020.
8
From Inflammation to Cutaneous Repair: Topical Application of Lupeol Improves Skin Wound Healing in Rats by Modulating the Cytokine Levels, NF-κB, Ki-67, Growth Factor Expression, and Distribution of Collagen Fibers.从炎症到皮肤修复：羽扇豆醇的局部应用通过调节细胞因子水平、NF-κB、Ki-67、生长因子表达和胶原纤维分布改善大鼠皮肤伤口愈合。
Int J Mol Sci. 2020 Jul 13;21(14):4952. doi: 10.3390/ijms21144952.
9
Effect of Clausena excavata Burm. f. (Rutaceae) leaf extract on wound healing and antioxidant activity in rats.鹰不泊（芸香科）叶提取物对大鼠伤口愈合及抗氧化活性的影响
Drug Des Devel Ther. 2015 Jul 13;9:3507-18. doi: 10.2147/DDDT.S84770. eCollection 2015.
10
Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats.姜黄素的抗氧化和抗炎潜力加速了链脲佐菌素诱导的糖尿病大鼠的皮肤伤口愈合。
Int Immunopharmacol. 2014 Jun;20(2):322-30. doi: 10.1016/j.intimp.2014.03.009. Epub 2014 Mar 24.

引用本文的文献

1
Retracted: Promotes Healing of Excised Wounds in Rat Skin: Emphasis on Its Collagen-Enhancing, Antioxidant, and Anti-Inflammatory Activities.撤回：促进大鼠皮肤切除伤口愈合：着重于其增强胶原蛋白、抗氧化和抗炎活性。
Oxid Med Cell Longev. 2023 Oct 4;2023:9840217. doi: 10.1155/2023/9840217. eCollection 2023.
2
Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats.基于阿米替林的可生物降解聚乙二醇-聚乳酸-羟基乙酸共聚物自组装纳米颗粒加速糖尿病大鼠皮肤伤口愈合
Pharmaceutics. 2022 Aug 26;14(9):1792. doi: 10.3390/pharmaceutics14091792.
3
The Use of Menthol in Skin Wound Healing-Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization.

本文引用的文献

1
Collagen extract obtained from Nile tilapia (Oreochromis niloticus L.) skin accelerates wound healing in rat model via up regulating VEGF, bFGF, and α-SMA genes expression.从尼罗罗非鱼（Oreochromis niloticus L.）皮中提取的胶原蛋白通过上调 VEGF、bFGF 和 α-SMA 基因的表达促进大鼠模型的伤口愈合。
BMC Vet Res. 2020 Sep 24;16(1):352. doi: 10.1186/s12917-020-02566-2.
2
Euryops arabicus displays anti-inflammatory activities in experimental models.阿拉伯茶显示出在实验模型中具有抗炎活性。
J Ethnopharmacol. 2020 Jan 30;247:112278. doi: 10.1016/j.jep.2019.112278. Epub 2019 Oct 4.
3
Skin Acute Wound Healing: A Comprehensive Review.
薄荷醇在皮肤伤口愈合中的应用——抗炎潜力、抗氧化防御系统刺激及上皮形成增加
Pharmaceutics. 2021 Nov 9;13(11):1902. doi: 10.3390/pharmaceutics13111902.
皮肤急性伤口愈合：全面综述
Int J Inflam. 2019 Jun 2;2019:3706315. doi: 10.1155/2019/3706315. eCollection 2019.
4
Wound Healing: A Cellular Perspective.创伤愈合：细胞视角。
Physiol Rev. 2019 Jan 1;99(1):665-706. doi: 10.1152/physrev.00067.2017.
5
Wound Healing Properties of Selected Natural Products.某些天然产物的伤口愈合特性。
Int J Environ Res Public Health. 2018 Oct 25;15(11):2360. doi: 10.3390/ijerph15112360.
6
Adipose-derived stem cells: Effectiveness and advances in delivery in diabetic wound healing.脂肪来源干细胞：在糖尿病创面愈合中有效性和传递方法的进展。
Biomed Pharmacother. 2018 Nov;107:625-633. doi: 10.1016/j.biopha.2018.08.013. Epub 2018 Aug 14.
7
Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats.大戟科大戟属植物斑地锦对四氧嘧啶诱导的糖尿病大鼠的伤口愈合作用。
BMC Complement Altern Med. 2017 Aug 24;17(1):423. doi: 10.1186/s12906-017-1930-x.
8
The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation.IKK、NF-κB和RIPK1信号通路在细胞死亡、组织稳态和炎症调节中的相互作用。
Immunol Rev. 2017 May;277(1):113-127. doi: 10.1111/imr.12550.
9
The Practice of Ethnomedicine in the Northern and Southern Provinces of Oman.阿曼南北两省的民族医学实践
Oman Med J. 2016 Jul;31(4):245-52. doi: 10.5001/omj.2016.49.
10
Wound healing activity of the ethanol root extract and polyphenolic rich fraction from Potentilla fulgens.金露梅乙醇根提取物及其多酚丰富部分的伤口愈合活性。
Pharm Biol. 2016 Nov;54(11):2383-2393. doi: 10.3109/13880209.2016.1157192. Epub 2016 Apr 4.