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[膀胱肿瘤患者移行上皮细胞机械整合及免疫状态的变化]

[Changes in the mechanical integration of transitional epithelial cells and in the immune status of patients with bladder tumors].

作者信息

Bocharova O A, Serebriakova R V, Golubeva V A, Figurin K M, Bukharkin B V, Bodrova N B, Matveev B P, Baryshnikov A Iu

出版信息

Urol Nefrol (Mosk). 1994 May-Jun(3):27-30.

PMID:8079407
Abstract

Mutual adhesiveness of urothelial tissue cells have been studied in healthy donors and patients with benign and malignant bladder tumors. The decreased mutual adhesiveness has been shown not only for tumors, but for surrounding urothelial tissue as well. Urothelial tissue integration, T-cell immunity and parameters of leukocyte integrins were affected most of all in bladder tumor stage T2 and T3. Basing on these findings, the authors recommend conservative therapy only in superficial bladder cancer.

摘要

已对健康供体以及患有良性和恶性膀胱肿瘤的患者的尿路上皮组织细胞的相互黏附性进行了研究。结果表明,不仅肿瘤细胞,而且周围的尿路上皮组织的相互黏附性均降低。在膀胱肿瘤T2和T3期,尿路上皮组织整合、T细胞免疫和白细胞整合素参数受影响最大。基于这些发现,作者建议仅对浅表性膀胱癌采用保守治疗。

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