Pletsityĭ K D, Davydova T V, Fomina V G
Vopr Med Khim. 1994 May-Jun;40(3):51-3.
Chronic alcohol intoxication of mice CBA and C57BL/6 strains decreased distinctly the content of T lymphocytes in peripheric blood and inhibited the immune response to sheep erythrocytes. Vitamin E, administered into mice at a dose of 5 IU and into guinea pigs--of 50 IU within 3 days, restored completely the immunity status of these animals. Besides, vitamin E decreased ethanol consumption in mice kept under conditions of alternative choice of water-ethanol within one week after its injection.
CBA和C57BL/6品系小鼠的慢性酒精中毒显著降低了外周血中T淋巴细胞的含量,并抑制了对绵羊红细胞的免疫反应。以5国际单位的剂量给小鼠注射维生素E,以50国际单位的剂量给豚鼠在3天内注射维生素E,可完全恢复这些动物的免疫状态。此外,维生素E在注射后一周内,可降低处于水-乙醇交替选择条件下的小鼠的乙醇消耗量。