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[全氟碳乳剂的免疫效应]

[The immunological effects of perftoran].

作者信息

Pluzhnikov N N, Lobzin Iu V, Kovelenov A Iu, Zhelezkova E V, Gusev D A

机构信息

Department of Infectious Diseases, St. Petersburg Military Medical Academy, Russia.

出版信息

Eksp Klin Farmakol. 1998 Sep-Oct;61(5):34-6.

PMID:9854631
Abstract

The effect of perftocarbonic emulsion-perftoran on the course of experimental lipopolysaccharide intoxication was studied in albino mice. Resistance of the animals to the endotoxin reduced 3 days after administration of 10 ml/kg of the preparation and increased 6 days after its administration. The effect of perftoran on the dynamics of some parameters of immunity and nonspecific resistance in CBA mice and guinea pigs was studied in immunodeficiency states induced by injection of 5-fluorouracil, cyclophosphamide, and irradiation. Activation of the phagocytic system occurred 3 days later, and activation of the parameters of cellular and humoral immunity 6 days later.

摘要

在白化病小鼠中研究了全氟碳酸乳剂-全氟烷对实验性脂多糖中毒病程的影响。给予10ml/kg制剂3天后,动物对内毒素的抵抗力降低,给药6天后抵抗力增加。在通过注射5-氟尿嘧啶、环磷酰胺和照射诱导的免疫缺陷状态下,研究了全氟烷对CBA小鼠和豚鼠某些免疫和非特异性抵抗力参数动态的影响。3天后吞噬系统被激活,6天后细胞免疫和体液免疫参数被激活。

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