Rothenberger A, Moll G H
Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim, Germany.
Acta Paedopsychiatr. 1994;56(3):209-18.
Contrary to the current assumption that there are no specific correlates of dyslexia in the standard clinical EEG, we have often noted a spontaneous "intermittent left parietal alpha desynchronization" (ILPAD) when visually evaluating the standard EEGs of children with delayed speech and language development and/or dyslexia. Visual evaluations of EEGs, as well as computer-assisted frequency analysis of three pairs of matched groups (healthy and hyperkinetic children with vs. without relatively "low levels" of verbal performance, as well as children with other child psychiatric disorders with vs. without dyslexia), revealed that healthy children did not display the ILPAD phenomenon. It was seen neither in healthy children with a homogeneous performance profile ("high level" of verbal performance) nor in those with a relatively "low level" of verbal performance. However, the ILPAD phenomenon was evident mainly in children with psychiatric disorders who suffered from dyslexia. Its intermittent occurrence prevented its detection by means of the usual computer-supported analyses of EEG power spectra. Nevertheless, auditory cognitive loading was accompanied by a decrease in alpha power in both healthy and hyperkinetic children with "high" or "low" levels of verbal performance. In a further group of 8-year-old children with dyslexia, but otherwise healthy, the ILPAD phenomenon was also observed if their CNS maturation as reflected in the EEG was normal for their age. These results seemed to indicate at least a deficit-specificity of the ILPAD phenomenon, which is interpreted as an electrophysiological correlate of a "brain-electrical developmental deviation" with regard to the "functions of communication": speech, language, reading and spelling.
与目前认为在标准临床脑电图中不存在诵读困难的特定相关因素的假设相反，我们在对语言发育迟缓及/或诵读困难儿童的标准脑电图进行视觉评估时，经常注意到一种自发的“间歇性左顶叶阿尔法去同步化”（ILPAD）现象。对脑电图的视觉评估以及对三组匹配组（健康儿童与多动儿童，言语表现相对“低水平”与非相对“低水平”，以及患有其他儿童精神疾病的儿童伴有与不伴有诵读困难）的计算机辅助频率分析显示，健康儿童未表现出ILPAD现象。在言语表现均匀（“高水平”言语表现）的健康儿童以及言语表现相对“低水平”的健康儿童中均未发现该现象。然而，ILPAD现象主要在患有诵读困难的精神疾病儿童中明显。其间歇性出现使得通过通常的计算机支持的脑电图功率谱分析难以检测到它。尽管如此，在言语表现“高”或“低”水平的健康儿童和多动儿童中，听觉认知负荷均伴随着阿尔法功率的降低。在另一组8岁但其他方面健康的诵读困难儿童中，如果脑电图所反映的他们的中枢神经系统成熟度与其年龄相符，也观察到了ILPAD现象。这些结果似乎至少表明了ILPAD现象的缺陷特异性，这被解释为在“沟通功能”（言语、语言、阅读和拼写）方面“脑电发育偏差”的一种电生理相关因素。
