Lin Y H, Zhang J J, Chen W W
Central Laboratory, Beijing College of Traditional Chinese Medicine.
Yao Xue Xue Bao. 1994;29(3):171-5.
This paper reports the protective effect of sodium ferulate (SF) on mitochondrial morphology and functions. Sodium ferulate was found to significantly inhibit the mitochondria abnormal swelling and TBA reaction induced by Fe2+/Vit C system. This compound was also shown to modulate the uncoupling effect of malondialdehyde (MDA) on oxidative phosphorylation of mitochondria. Respiratory control rate for blank, MDA and MDA+SF were 4.75, 3.64 and 4.50 respectively. SF was shown to inhibit the cross reaction of MDA with biological macromolecules of rat liver mitochondria assayed by SDS-polyacrylamide gel electrophoresis. The results suggest that the injury action of oxygen free radicals to rat liver mitochondria can be prevented by SF.
本文报道了阿魏酸钠（SF）对线粒体形态和功能的保护作用。研究发现阿魏酸钠能显著抑制由Fe2+/维生素C体系诱导的线粒体异常肿胀和TBA反应。该化合物还能调节丙二醛（MDA）对线粒体氧化磷酸化的解偶联作用。空白组、MDA组和MDA+SF组的呼吸控制率分别为4.75、3.64和4.50。通过SDS-聚丙烯酰胺凝胶电泳分析表明，阿魏酸钠能抑制MDA与大鼠肝线粒体生物大分子的交叉反应。结果表明，阿魏酸钠可预防自由基对大鼠肝线粒体的损伤作用。
