藤茶黄酮对清除氧自由基及抑制脂质过氧化的作用
[Effects of tengcha flavonoids on scavenging oxygen free radicals and inhibiting lipid-peroxidation].
作者信息
He Guixia, Du Fanglu, Yang Weili, Pei Gang, Zhu Yonghua
机构信息
Hunan College of Traditional Chinese Medicine, Changsha 410007.
出版信息
Zhong Yao Cai. 2003 May;26(5):338-40.
OBJECTIVE
To study the effects of Tengcha flavonoids (TCF) on scavenging oxygen free radicals and inhibiting lipid-peroxidation.
METHODS
The effects of TCF on scavenging superoxide anion radical induced by xanthine-xanthine oxidase, inhibiting lipid-peroxidation of heart, liver, brain tissue homogenate and mitochondria induced by Fe2+ -VitC, Fe2+ -H2O2, Fe-Cys were discussed by TBA spectrometric method.
RESULTS
TCF could significantly inhibit the superoxide anion radical, IC50 is 14.7 mg/L, and the lipid peroxidation of liver homogenate and mitochondria induced by auto-oxidation and induced-oxidation. The inhibition exhibited concentration-dependent manner.
CONCLUSION
It indicated that TCF could scavenge oxygen free radicals and was capable of prophylacticly antagonizing against the oxidative injury by superoxide anion.
目的
研究藤茶黄酮（TCF）清除氧自由基及抑制脂质过氧化的作用。
方法
采用TBA比色法探讨TCF对黄嘌呤 - 黄嘌呤氧化酶诱导产生的超氧阴离子自由基的清除作用，以及对Fe2+ - VitC、Fe2+ - H2O2、Fe - Cys诱导的心脏、肝脏、脑组织匀浆及线粒体脂质过氧化的抑制作用。
结果
TCF能显著抑制超氧阴离子自由基，IC50为14.7 mg/L，对自氧化和诱导氧化所致的肝脏匀浆及线粒体脂质过氧化均有抑制作用，且呈浓度依赖性。
结论
表明TCF能清除氧自由基，对超氧阴离子所致的氧化损伤有预防性拮抗作用。
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