Bräuer R, Kette H, Henzgen S, Thoss K
Institute of Pathology, Friedrich Schiller University, Jena, Germany.
Agents Actions. 1994 Mar;41(1-2):96-8. doi: 10.1007/BF01986404.
The effects of the T-cell-directed immunosuppressant cyclosporin A (CsA) on the development of antigen-induced arthritis (AIA) in rats as well as on cytokine levels in synovial fluid and serum were determined. The treatment with CsA effectively inhibited the chronic phase of arthritis as demonstrated by decreased joint swelling and reduced histological arthritic score. In animals with AIA the level of IL-6 in the synovial fluid and serum is increased, showing good correlation with the severity of the disease. The CsA treatment reduced IL-6 levels to normal. IL-1, IL-2 and TNF-alpha do not seem to be directly involved in the pathogenic mechanisms of chronic arthritis.
研究了针对T细胞的免疫抑制剂环孢素A（CsA）对大鼠抗原诱导性关节炎（AIA）发展的影响以及对滑液和血清中细胞因子水平的影响。CsA治疗有效抑制了关节炎的慢性期，表现为关节肿胀减轻和组织学关节炎评分降低。在患有AIA的动物中，滑液和血清中IL-6水平升高，与疾病严重程度呈良好相关性。CsA治疗使IL-6水平降至正常。IL-1、IL-2和TNF-α似乎未直接参与慢性关节炎的致病机制。
