Falangola M F, Castro-Filho B G, Petito C K
Department of Pathology, University of Miami School of Medicine, FL 33136.
Ann Neurol. 1994 Sep;36(3):437-40. doi: 10.1002/ana.410360316.
We identified immune complex deposits in the choroid plexus of approximately 75% of patients with acquired immunodeficiency syndrome (AIDS) who had either normal brains or human immunodeficiency virus encephalitis. Since circulating immune complexes are common in AIDS patients, and since local choroid plexus pathology usually was absent, their likely origin is from the bloodstream. Choroid plexus deposits of immune complexes have been implicated in altering the function of this structure or in enhancing its vulnerability to infection. Therefore, immune complex deposition in the choroid plexus of AIDS patients may be responsible for some of the common alterations in the cerebrospinal fluid and for the frequency of opportunistic infections in this region.
我们在约75%患有获得性免疫缺陷综合征（AIDS）的患者脉络丛中发现了免疫复合物沉积，这些患者脑部要么正常，要么患有人类免疫缺陷病毒脑炎。由于循环免疫复合物在艾滋病患者中很常见，且脉络丛局部通常无病理改变，其可能起源于血液。免疫复合物在脉络丛中的沉积被认为与该结构功能改变或其对感染易感性增加有关。因此，艾滋病患者脉络丛中的免疫复合物沉积可能是脑脊液一些常见改变以及该区域机会性感染频发的原因。
