Yang Z M, Le S P, Chen D B, Harper M J
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Mol Reprod Dev. 1994 Jun;38(2):148-52. doi: 10.1002/mrd.1080380205.
Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to document the appearance of LIF in the rabbit uterus during early pregnancy and to determine whether changes just prior to implantation, similar to those in mice, occurred. LIF was localized in endometrial epithelium, myometrium, and endometrial glands. A low level of LIF was detected in the uterus of nonestrous and estrous females. LIF expression reached its highest level on day 5 of pregnancy and declined on days 6 and 7. By day 13 of pregnancy, little endometrial LIF was apparent. The expression of LIF on day 5 of pseudopregnancy was similar to that on day 5 of pregnancy. LIF expression was much higher at implantation sites than that at nonimplantation areas on day 7 of pregnancy. It is concluded that LIF may be important for the implantation of rabbit blastocysts.
白血病抑制因子（LIF）已被证明在小鼠囊胚着床过程中发挥重要作用。本研究旨在记录妊娠早期兔子宫中LIF的出现情况，并确定在着床前是否会发生类似于小鼠的变化。LIF定位于子宫内膜上皮、子宫肌层和子宫内膜腺体。在未发情和发情雌性的子宫中检测到低水平的LIF。LIF表达在妊娠第5天达到最高水平，并在第6天和第7天下降。到妊娠第13天，子宫内膜LIF几乎消失。假孕第5天LIF的表达与妊娠第5天相似。在妊娠第7天，着床部位的LIF表达远高于非着床部位。结论是LIF可能对兔囊胚的着床很重要。
