Bhatt Narendra, Deshpande Manasi
CRIA Consultant Pvt. Ltd. Mumbai, Mumbai, India.
Department of DravyagunaVigynan, Bharati Vidyapeeth Deemed to be University, College of Ayurved, Pune, India.
Front Pharmacol. 2021 Jun 3;12:629591. doi: 10.3389/fphar.2021.629591. eCollection 2021.
Commonly used synthetic or prescribed hormonal drugs are known to interfere with the endocrine system and may have adverse reproductive, neurological, developmental, and metabolic effects in the body. These may also produce adverse effects such as polycystic ovarian disorder, endometriosis, early puberty, infertility or toxicity to gonads, testicular germ cell cancer, breast or prostate cancer, brain developmental problems, and even birth defects. Globally, the emergence of renewed interest in natural products for reproductive health is on the rise, which offers opportunities for new contraceptive developments. The search for alternate, safer contraceptive products or agents of natural origin is of scientific interest. Ayurvedic classical texts offer knowledge and information about the reproductive function and therapeutics including those for enhancement and limiting male and female fertility. Review of ancient, medieval, and recent-including texts on erotica that provide information on approaches and large numbers of formulations and drugs of plant, mineral or animal origin-claimed to have sterilizing, contraceptive, abortifacient, and related properties is presented. Few among these are known to be toxic and few are not so common. However, most of the formulations, ingredients, or modes of administration have remained unattended to, due to issues related to consumer compliance and limitations of standardization and lack of appropriate validation modalities. Several of these ingredients have been studied for their phytoconstituents and for the variety of pharmacological activities. Efforts to standardize several classical dosage forms and attempts to adapt to modern technologies have been made. List of formulations, ingredients, and their properties linked with known constituents, pharmacological, biological, and toxicity studies have been provided in a series of tables. The possible effectiveness and safety of selected formulations and ingredients have been examined. Suggestions based on new drug delivery systems integrated with advances in biotechnology, to provide prospects for new therapeutics for contraception, have been considered. Ayurveda is built on a holistic paradigm of biological entity rather than limited gonadal functions. Graphic presentation of a few carefully chosen possibilities has been depicted. New approaches to standardization and ethnopharmacological validation of natural contraceptive therapeutics may offer novel mechanisms and modalities and therapeutic opportunities to satisfy unmet needs of contraception.
已知常用的合成激素药物或处方激素药物会干扰内分泌系统，并可能对身体产生不良的生殖、神经、发育和代谢影响。这些药物还可能产生诸如多囊卵巢症、子宫内膜异位症、性早熟、不孕或对性腺的毒性、睾丸生殖细胞癌、乳腺癌或前列腺癌、大脑发育问题，甚至出生缺陷等不良反应。在全球范围内，人们对用于生殖健康的天然产品的兴趣再度兴起，这为新型避孕药具的开发提供了机遇。寻找替代的、更安全的天然避孕产品或制剂具有科学意义。阿育吠陀经典文献提供了有关生殖功能和治疗方法的知识和信息，包括增强和限制男性及女性生育能力的方法。本文回顾了古代、中世纪以及近期的文献，包括色情文学方面的文献，这些文献提供了有关各种方法以及大量声称具有绝育、避孕、堕胎及相关特性的植物、矿物或动物来源的配方和药物的信息。其中很少有已知有毒的，也很少有不常见的。然而，由于消费者依从性问题、标准化限制以及缺乏适当的验证方式，大多数配方、成分或给药方式仍未得到关注。其中一些成分已针对其植物成分和多种药理活性进行了研究。人们已努力对几种经典剂型进行标准化，并尝试采用现代技术。一系列表格中列出了配方、成分及其与已知成分、药理、生物学和毒性研究相关的特性。已对所选配方和成分的可能有效性和安全性进行了研究。基于与生物技术进展相结合的新药物递送系统的建议，为新型避孕疗法提供了前景。阿育吠陀建立在生物实体的整体范式之上，而非局限于性腺功能。文中描绘了一些精心挑选的可能性的图表展示。天然避孕疗法的标准化和民族药理学验证的新方法可能会提供新的机制、方式和治疗机会，以满足未满足的避孕需求。
