Lallement G, Pernot-Marino I, Foquin-Tarricone A, Baubichon D, Piras A, Blanchet G, Carpentier P
Unité de Neurotoxicologie, Centre de Recherches du Service de Sauté des Armées, La Tronche, France.
Neuroreport. 1994 May 9;5(9):1113-7. doi: 10.1097/00001756-199405000-00023.
The ability of relatively low doses of atropine, NBQX and TCP administered in combination to prevent or stop seizures induced by soman, was studied in rats. While these drugs injected together early after soman prevented the onset of seizures, their delayed concomitant administration after 5 or 30 min of epileptic activity only mildly attenuated the intensity of seizures. Conversely, a total arrest of epileptic activity was observed in 80 to 100% of animals when NBQX and TCP were given together after 5 to 50 min of seizures to atropine pretreated rats. The large time-window for antiepileptic effectiveness of this 'three drug treatment', provided that atropine is administered early after soman, is discussed in relation to reciprocal potentiations of the antiepileptic effects of atropine, NBQX and TCP in combination.
研究了联合给予相对低剂量的阿托品、NBQX和TCP预防或阻止大鼠沙林诱导癫痫发作的能力。虽然在沙林中毒后早期一起注射这些药物可预防癫痫发作的发生，但在癫痫活动5或30分钟后延迟同时给药仅轻度减弱癫痫发作的强度。相反，在给予阿托品预处理的大鼠癫痫发作5至50分钟后，将NBQX和TCP一起给药时，80%至100%的动物癫痫活动完全停止。鉴于阿托品在沙林中毒后早期给药，讨论了这种“三联药物治疗”抗癫痫有效性的较大时间窗与阿托品、NBQX和TCP联合抗癫痫作用的相互增强有关。
