Friedman E M, Coe C L, Ershler W B
Department of Psychology, University of Wisconsin, Madison 53706.
Brain Behav Immun. 1994 Jun;8(2):87-99. doi: 10.1006/brbi.1994.1009.
Physiological and pharmacological doses of recombinant human interleukin-1 (IL-1) were administered intravenously to juvenile rhesus monkeys in order to evaluate its effects on immune and endocrine activity. Mitogen-induced lymphocyte proliferation was increased following 1-ng and 1-microgram doses of IL-1, but decreased following 10- and 50-micrograms doses. Natural killer cell cytotoxicity was also significantly reduced at the 10-micrograms dose and tended to be below baseline at the 50-micrograms dose. These changes were associated with marked neutrophilia observed after administration of IL-1. These results indicate that peripheral administration of IL-1 can either enhance or inhibit the numbers and responses of immune cells in rhesus monkeys depending on the dose administered. These responses may have been the result of differential activation of the endocrine system, because levels of pituitary hormones in plasma increased progressively with increasing doses of IL-1. Thus, the extent to which a particular dose of IL-1 induces the release of pituitary-adrenal hormones may be related to the direction and magnitude of the resulting changes in immune activity.
为了评估重组人白细胞介素-1（IL-1）对幼年恒河猴免疫和内分泌活性的影响，将生理剂量和药理剂量的重组人白细胞介素-1静脉注射给幼年恒河猴。在给予1纳克和1微克剂量的IL-1后，丝裂原诱导的淋巴细胞增殖增加，但在给予10微克和50微克剂量后降低。在10微克剂量时，自然杀伤细胞的细胞毒性也显著降低，在50微克剂量时趋于低于基线水平。这些变化与给予IL-1后观察到的明显中性粒细胞增多有关。这些结果表明，外周给予IL-1可以增强或抑制恒河猴免疫细胞的数量和反应，这取决于所给予的剂量。这些反应可能是内分泌系统差异激活的结果，因为血浆中垂体激素水平随着IL-1剂量的增加而逐渐升高。因此，特定剂量的IL-1诱导垂体-肾上腺激素释放的程度可能与免疫活性变化的方向和幅度有关。
