Lubach G R, Coe C L, Ershler W B
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53706, USA.
Brain Behav Immun. 1995 Mar;9(1):31-46. doi: 10.1006/brbi.1995.1004.
In animals, perturbations of the rearing environment have been shown to alter behavior, cognition, and physiology, including immune responses. In order to evaluate the effect of early rearing conditions on the development of immune responses in the infant primate, several immunological measures were assessed in rhesus monkey infants, nursery-reared (NR) or mother-reared (MR), from birth to 2 years of age. Rearing in the absence of the mother affected several aspects of cellular immunity. NR monkeys had significantly lower proportions of CD8 cells and lower natural killer cell activity than did MR monkeys. In contrast, their lymphocyte proliferation responses to mitogen stimulation were higher than those of MR monkeys. An attempt to behaviorally rehabilitate the NR infants at 1 year of age did not result in a recovery of normal immune responses. This study indicates that abnormal early rearing may have long-lasting effects on the immune system, which could have health consequences later in life.
在动物中，饲养环境的扰动已被证明会改变行为、认知和生理，包括免疫反应。为了评估早期饲养条件对幼年灵长类动物免疫反应发育的影响，对恒河猴幼崽从出生到2岁进行了评估，这些幼崽分别在保育室饲养（NR）或由母亲抚养（MR），并采用了多种免疫学测量方法。缺乏母亲抚养会影响细胞免疫的多个方面。与MR猴子相比，NR猴子的CD8细胞比例显著更低，自然杀伤细胞活性也更低。相反，它们对有丝分裂原刺激的淋巴细胞增殖反应高于MR猴子。在1岁时尝试对NR幼崽进行行为康复训练，并未使免疫反应恢复正常。这项研究表明，早期异常饲养可能会对免疫系统产生长期影响，这可能会在以后的生活中对健康造成影响。
