拉莫三嗪与丙戊酸钠在难治性肌阵挛性癫痫中的治疗相互作用。
Therapeutic interaction of lamotrigine and sodium valproate in intractable myoclonic epilepsy.
作者信息
Ferrie C D, Panayiotopoulos C P
机构信息
Department of Clinical Neurophysiology and Epilepsy, St Thomas' Hospital London, UK.
出版信息
Seizure. 1994 Jun;3(2):157-9. doi: 10.1016/s1059-1311(05)80208-0.
PMID:8081644
Abstract
The clinical and EEG features of a 13-year-old girl with an unusual refractory myoclonic epilepsy is presented. Control was achieved only when lamotrigine was combined with sodium valproate. This may represent a specific pharmacodynamic interaction between these drugs with implications for therapy in the generalized epilepsies.
摘要
本文介绍了一名13岁患有罕见难治性肌阵挛癫痫女孩的临床和脑电图特征。仅当拉莫三嗪与丙戊酸钠联合使用时才实现了病情控制。这可能代表了这些药物之间特定的药效学相互作用，对全身性癫痫的治疗具有启示意义。
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