Effect of simultaneous administration of polychlorinated biphenyls and alkylbenzene sulfonic acid salt in rats.

Administration of PCB to rats resulted in an increase in lever weight, hypertrophy with foam-like changes in cytoplasm of individual liver cells, an increase in liver cholesterol levels, an increase in lever aniline hydroxylase activity and a decrease in liver Na-K-Mg-dependent APTase activity. When ABS was simultaneously administered with PCB, most of the above-mentioned abnormalities were observed to increase and were dependent on administration time and dosage. Testicular abnormalities were observed only in rats on long term co-administration of PCB and ABS.