Itokawa Y, Tabei R, Kamohara K, Fujiwara K
Arch Environ Contam Toxicol. 1975;3(2):115-31. doi: 10.1007/BF02220782.
Administration of PCB to rats resulted in an increase in lever weight, hypertrophy with foam-like changes in cytoplasm of individual liver cells, an increase in liver cholesterol levels, an increase in lever aniline hydroxylase activity and a decrease in liver Na-K-Mg-dependent APTase activity. When ABS was simultaneously administered with PCB, most of the above-mentioned abnormalities were observed to increase and were dependent on administration time and dosage. Testicular abnormalities were observed only in rats on long term co-administration of PCB and ABS.
给大鼠施用多氯联苯导致肝脏重量增加、肝细胞胞质肥大并伴有泡沫样变化、肝脏胆固醇水平升高、肝脏苯胺羟化酶活性增加以及肝脏钠钾镁依赖性ATP酶活性降低。当同时给大鼠施用多氯联苯和烷基苯磺酸盐时，上述大多数异常情况会加剧，且取决于给药时间和剂量。仅在长期同时施用多氯联苯和烷基苯磺酸盐的大鼠中观察到睾丸异常。
