Zofková I, Röjdmark S, Kancheva R L
Institute of Endocrinology, Prague, Czech Republic.
Calcif Tissue Int. 1994 Jun;54(6):521-2. doi: 10.1007/BF00334336.
Estrogen influences the calcium-induced suppressibility of parathyroid hormone (PTH) in postmenopausal women. We tested the hypothesis that parathyroid gland function is also sensitive to the anabolic steroid, stanazolol. The calcium-induced suppressibility of PTH was investigated in 11 osteoporotic postmenopausal women on two occasions, before and after 1 month's oral treatment with stanazolol. Compliance to treatment was checked by the determination of serum luteinizing hormone (LH) and testosterone. Serum intact PTH and ionized calcium were estimated before and 5, 60, and 120 minutes after I.V. calcium load. Calcium-induced PTH suppression was of a similar magnitude before and after stanazolol, although calcium increments were identical. The results imply that stanazolol--at biologically effective doses--does not affect PTH responsiveness to hypercalcemia in postmenopausal women.
雌激素会影响绝经后女性甲状旁腺激素（PTH）的钙诱导抑制作用。我们检验了甲状旁腺功能对合成代谢类固醇司坦唑醇也敏感这一假说。在11名绝经后骨质疏松女性中，在口服司坦唑醇治疗1个月前后两个阶段，研究了PTH的钙诱导抑制作用。通过测定血清促黄体生成素（LH）和睾酮来检查治疗依从性。在静脉注射钙负荷前以及注射后5、60和120分钟，测定血清完整PTH和离子钙。尽管钙增量相同，但司坦唑醇治疗前后钙诱导的PTH抑制程度相似。结果表明，在生物有效剂量下，司坦唑醇不会影响绝经后女性PTH对高钙血症的反应性。
