Xu G, Duanmu Z, Yin Q
Laboratory of Neurobiology, Suzhou Medical College, Jiangsu.
Zhen Ci Yan Jiu. 1993;18(1):1-5, 7.
This article reviews the main results in recent years of studies on the role of central Ach in pain modulation and analgesia, including: (1) cholinergically induced analgesia (CIA). Cholinomimetic drugs raised the pain threshold or inhibited the unit discharges of hypothalamus parafascicularis nuclens in rats, and these actions were revised by atropine not by nicotine. (2) Ach and acupuncture analgesia (AA). The effect of electroacupuncture was changed by administration of HC-3, atropine, etc. (3) Ach and stress analgesia (SA). Scopolamine reduced the hind foot shock induced analgesia, and this kind of SA was probably mediated by m-receptors existed at supraspinal, rather than spinal level. Swimming and immobilization analgesia were also related to Ach. These data suggested that the central cholinergic system is very important in pain modulation and analgesia and the central Ach is essential transmitter or modulator in this analgesic pathway. But the problem is whether the mechanism of CIA is involved in opiate analgesic system or not.
本文综述了近年来关于中枢乙酰胆碱在疼痛调制和镇痛中作用的主要研究结果，包括：（1）胆碱能诱导镇痛（CIA）。拟胆碱药物提高了大鼠的痛阈或抑制了下丘脑束旁核的单位放电，且这些作用可被阿托品而非尼古丁所翻转。（2）乙酰胆碱与针刺镇痛（AA）。给予HC-3、阿托品等药物可改变电针的效果。（3）乙酰胆碱与应激镇痛（SA）。东莨菪碱可减弱后足电击诱导的镇痛作用，且这种应激镇痛可能是由脊髓以上而非脊髓水平存在的M受体介导的。游泳和制动镇痛也与乙酰胆碱有关。这些数据表明，中枢胆碱能系统在疼痛调制和镇痛中非常重要，中枢乙酰胆碱是该镇痛途径中必不可少的递质或调制物。但问题在于，胆碱能诱导镇痛的机制是否涉及阿片类镇痛系统。
