Guan X, Liang X, Liu X
Department of Neurobiology, Tongji Medical University, Wuhan.
Zhen Ci Yan Jiu. 1990;15(2):136-9.
In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor--Neostigmine and the ACh synthesis blocker--Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats. The results indicated that: 1) The effect of electroacupuncture analgesia can be enhanced by subcutaneous injection of neostigmine which related to the dosage used. 2) The influence of electroacupuncture analgesia can be markedly inhibited by intraperitoneal injection of Hemicholine. 3) This influence of suppression by Hemicholine can be reversed at once when acetylcholine in combination with neostigmine was injected. But could not reverse by neostigmine alone. It suggested that the effect of electroacupuncture analgesia and the primary input of acupuncture sensation were significantly related to the level and content of ACh in periphery.
为探讨外周乙酰胆碱（ACh）与针刺感觉的初级传入之间的相关性，本文采用不能透过血脑屏障的胆碱酯酶抑制剂——新斯的明和ACh合成阻滞剂——半胆碱，以及ACh作为工具，来升高或降低大鼠外周神经系统中ACh的水平。结果表明：1）皮下注射新斯的明可增强电针镇痛效果，且与所用剂量有关。2）腹腔注射半胆碱可显著抑制电针镇痛作用。3）当将乙酰胆碱与新斯的明联合注射时，半胆碱的这种抑制作用可立即被逆转，但单独使用新斯的明则不能逆转。这提示电针镇痛效应和针刺感觉的初级传入与外周ACh的水平和含量显著相关。
