Anesi A, Franciotta D, Di Paolo E, Zardini E, Melzi d'Eril G V, Zerbi F
Laboratory of Clinical Chemistry, IRCCS, C. Mondino Foundation, Univesity of Pavia, Italy.
Funct Neurol. 1994 Jan-Feb;9(1):17-22.
We measured some immunological parameters in 20 hospitalized patients with major depression and 20 age- and sex-matched healthy controls. Both enumeration of immune cells, including T-lymphocyte subpopulations, and assay of T-cell function were studied. White blood cells were evaluated with an automated cell counter, T-cell subsets with an immunobead technique, and T-cell function with a phytohemagglutinin-induced proliferation in vitro assay. We found that T-lymphocyte responses to the mitogen were significantly lower in depressed patients than in controls. All the other parameters were normal. These findings suggest that functional but not numerical changes in T-lymphocytes characterize major depressive disorders.
我们对20例住院的重度抑郁症患者以及20名年龄和性别匹配的健康对照者进行了一些免疫参数的测量。研究了包括T淋巴细胞亚群在内的免疫细胞计数以及T细胞功能检测。使用自动血细胞计数器评估白细胞，采用免疫磁珠技术检测T细胞亚群，通过体外植物血凝素诱导增殖试验检测T细胞功能。我们发现，抑郁症患者对有丝分裂原的T淋巴细胞反应明显低于对照组。所有其他参数均正常。这些发现表明，T淋巴细胞的功能变化而非数量变化是重度抑郁症的特征。
