Muckerman D R
Department of Community Health and Medical Care, St. Louis, Mo.
J Am Osteopath Assoc. 1994 Jul;94(7):545-50, 555-7.
Human papillomavirus (HPV) infection, which has been linked to cervical dysplasia and carcinoma, causes one of the most frequently diagnosed sexually transmitted diseases (STDs) in the United States. To determine the prevalence of subclinical HPV infection, to detect any association with dysplasia, and to investigate risk factors, the author studied 249 sexually active adolescent girls and young women in a high-risk population by questionnaire, pelvic examination, cytology, and dot blot nucleic acid hybridization. The prevalence of subclinical HPV infection of the cervix was 10.4%. HPV-DNA positivity was associated with dysplasia, an increased number of sexual partners, and the part-time use of a birth control method. No association was found between subclinical HPV infection and race, cigarette smoking, oral contraceptive use, or the presence of other STDs. The use of HPV screening methods should be considered in select high-risk persons or groups.
人乳头瘤病毒（HPV）感染与宫颈发育异常和癌有关，是美国最常诊断出的性传播疾病（STD）之一。为了确定亚临床HPV感染的患病率，检测其与发育异常的任何关联，并调查危险因素，作者通过问卷调查、盆腔检查、细胞学检查和斑点印迹核酸杂交，对高危人群中的249名性活跃青春期女孩和年轻女性进行了研究。宫颈亚临床HPV感染的患病率为10.4%。HPV-DNA阳性与发育异常、性伴侣数量增加以及采用非全程的避孕方法有关。未发现亚临床HPV感染与种族、吸烟、口服避孕药使用或其他性传播疾病的存在之间存在关联。对于特定的高危人群或群体，应考虑使用HPV筛查方法。
