Hems T E, Clutton R E, Glasby M A
University of Edinburgh Medical School, Scotland, UK.
J Bone Joint Surg Br. 1994 Sep;76(5):818-23.
An experimental model was established to investigate the possibility of repairing cervical nerve roots avulsed from the spinal cord, as occurs in traction injuries of the brachial plexus. In five sheep the C6 root was avulsed and the ventral root was reattached using freeze-thawed muscle as a short graft (0.5 cm). Recovery was assessed after one year by electrophysiology and histology. Stimulation of the root produced muscle contractions in four out of five sheep. Action potentials were recorded distal to the grafts in all five sheep. Histological examination showed regenerated fibres in the ventral roots in all cases. These fibres could be traced distally to the brachial plexus. Our study confirms that motor fibres can regenerate out of the spinal cord into the ventral roots and reinnervate muscles, and suggests that reimplantation of avulsed roots is a surgical option in selected cases of traction injury of the brachial plexus.
建立了一个实验模型，以研究修复从脊髓撕脱的颈神经根的可能性，这种情况发生在臂丛神经牵拉伤中。在五只绵羊中，撕脱C6神经根，并使用冻融肌肉作为短移植物（0.5厘米）重新连接腹侧神经根。一年后通过电生理学和组织学评估恢复情况。刺激神经根在五只绵羊中的四只引起了肌肉收缩。在所有五只绵羊中，在移植物远端记录到了动作电位。组织学检查显示所有病例的腹侧神经根中均有再生纤维。这些纤维可以向远端追踪至臂丛神经。我们的研究证实运动纤维可以从脊髓再生进入腹侧神经根并重新支配肌肉，并表明在臂丛神经牵拉伤的特定病例中，撕脱神经根的再植入是一种手术选择。
