Schneble H
Dtsch Med Wochenschr. 1975 Jul 25;100(30):1564-7. doi: 10.1055/s-0028-1106422.
Fifteen epileptic patients with mild seizures of the narcolepsy type were treated with a combination of succinimide (average dose 750 mg) and dipropylacetate (average dose 1,200 mg), medication with each drug alone having brought no success. The combination of drugs stopped the seizures in eleven patients, in three they almost stopped and in one the frequency of seizures was halved. An E.E.G. was recorded in twelve, with improvement in each. Side effects occurred in five patients (nausea, vomiting, singultus and fatigue), but the drug had to be discontinued in only one instance.
15名患有发作性睡病型轻度癫痫发作的患者接受了琥珀酰亚胺(平均剂量750毫克)和二丙乙酸(平均剂量1200毫克)联合治疗,单独使用每种药物均未取得成功。联合用药使11名患者的癫痫发作停止,3名患者的发作几乎停止,1名患者的发作频率减半。对12名患者进行了脑电图记录,每名患者的脑电图均有改善。5名患者出现了副作用(恶心、呕吐、呃逆和疲劳),但仅1例患者不得不停药。