丙戊酸——儿童失神癫痫治疗中的临床疗效与血清浓度（作者译）
[Valproic acid -- clinical efficiency and serum concentration in the treatment of petit mal epilepsy in childhood (author's transl)].
作者信息
Fritsch G, Haidvogl M, Gleispach H, Ladurner G
出版信息
Padiatr Padol. 1981;16(4):481-8.
PMID:6795573
Abstract
28 children with Petit mal epilepsy were treated with valproic acid either as drug of primary choice or because of resistance to other antiepileptic drugs. Efficacy of treatment was measured by reduction of seizure frequency and EEG-recordings. Serum concentration of valproic acid was measured in all patients. The best clinical efficacy was found in children with absence seizures, who also required the lowest dosages. Side effects of therapy were (in most cases) transitory.
摘要
28名患有失神性癫痫的儿童接受了丙戊酸治疗，治疗药物要么是首选药物，要么是因为对其他抗癫痫药物耐药。通过癫痫发作频率的降低和脑电图记录来衡量治疗效果。对所有患者都测定了丙戊酸的血清浓度。失神发作的儿童临床疗效最佳，所需剂量也最低。治疗的副作用（大多数情况下）是暂时的。
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