Duyn J H, Mattay V S, Sexton R H, Sobering G S, Barrios F A, Liu G, Frank J A, Weinberger D R, Moonen C T
Laboratory of Diagnostic Radiology Research, OIR, NIH, Bethesda, Maryland 20892.
Magn Reson Med. 1994 Jul;32(1):150-5. doi: 10.1002/mrm.1910320123.
A 3-dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo-shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.
一种基于血氧水平依赖（BOLD）对比机制的三维磁共振成像（MRI）方法已被开发用于人类大脑的功能图谱绘制。该方法采用最近引入的回波偏移快速低角度激发（FLASH）原理，在20秒内获取单个三维数据集。使用8赫兹闪烁白光或变化的棋盘格图案进行视觉刺激，在配备标准头部线圈的传统1.5特斯拉临床扫描仪上对该技术进行了测试。在视觉皮层中识别出信号强度增加的区域，这与已知的功能组织一致。
