Rivas M, Voyer L, Tous M, Leardini N, de Mena M F, Wainsztein R, Callejo R, Prado V, Binsztein N
Instituto Nacional de Microbiología Carlos G. Malbrán, Buenos Aires, Argentina.
Medicina (B Aires). 1993;53(6):487-90.
We report a case of a child who developed Hemolytic Uremic Syndrome in whom two Shiga-like toxin (SLT)-producing Escherichia coli strains of different serotypes and genotypes, were simultaneously isolated from stools. In addition, one of these strains represented a new toxin producing serotype. Strain 1 belonged to serotype O157: H7, biotype D, produced SLT II and was susceptible to all antibiotics tested. This strain hybridized with gene probes for SLT II, fimbrial adhesion (EHEC factor) and attaching and effacing factor (eae). Strain 2 belonged to serotype 025: K2: H2, produced SLT II and had a multiresistant antibiotic susceptibility pattern. This strain hybridized with the EHEC gene probe but not with SLT I, SLT II and eae gene probes. Free fecal SLT II cytotoxin was detected in stools of the child and his father, suggesting that the infection may have been acquired from a household contact.
我们报告了一例患溶血尿毒综合征的儿童病例，从其粪便中同时分离出两株不同血清型和基因型的产志贺样毒素（SLT）的大肠杆菌菌株。此外，其中一株代表一种新的产毒素血清型。菌株1属于O157:H7血清型，生物型D，产SLT II，对所有测试抗生素敏感。该菌株与SLT II、菌毛黏附（肠出血性大肠杆菌因子）和紧密黏附因子（eae）的基因探针杂交。菌株2属于025:K2:H2血清型，产SLT II，具有多重耐药的抗生素敏感性模式。该菌株与肠出血性大肠杆菌基因探针杂交，但不与SLT I、SLT II和eae基因探针杂交。在该儿童及其父亲的粪便中检测到游离粪便SLT II细胞毒素，提示感染可能是通过家庭接触获得的。
