在大鼠孤束核中，将神经肽Y（1-36）或[亮氨酸31，脯氨酸34]神经肽Y与肾上腺素共同注射，可抵消对肾上腺素的血管减压反应。

Coinjections of NPY(1-36) or [Leu31,Pro34]NPY with adrenaline in the nucleus tractus solitarius of the rat counteract the vasodepressor responses to adrenaline.

作者信息

Yang S N, Fior D R, Hedlund P B, Narváez J A, Agnati L F, Fuxe K

机构信息

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

出版信息

Neurosci Lett. 1994 Apr 25;171(1-2):27-31. doi: 10.1016/0304-3940(94)90596-7.

DOI:10.1016/0304-3940(94)90596-7

PMID:8084492

Abstract

The cardiovascular effects of adrenaline microinjected alone or together with neuropeptide Y (NPY) receptor agonists into the nucleus tractus solitarius (Sol) of the anaesthetized rat have been investigated in order to evaluate NPY/adrenergic receptor interactions. In the dose range 0.05-20 nmol, adrenaline microinjected unilaterally into the Sol produced significant dose-related reductions in mean arterial blood pressure and heart rate. The vasodepressor action of a close to ED50 dose of adrenaline (0.5 nmol) was significantly counteracted by a threshold dose of NPY (1-36) (1 pmol) and of the NPY Y1 receptor agonist [Leu31,Pro34]NPY (2.5 pmol) microinjected into the Sol, but not by a threshold dose of NPY(13-36)(50 fmol), a selective Y2 receptor agonist. The present study provides evidence for an antagonistic NPY Y1/adrenergic receptor interaction in the Sol of the rat, involved in cardiovascular regulation.

摘要

为了评估神经肽Y（NPY）/肾上腺素能受体的相互作用，研究人员将肾上腺素单独或与NPY受体激动剂一起微量注射到麻醉大鼠的孤束核（Sol）中，并观察其对心血管系统的影响。在0.05 - 20 nmol的剂量范围内，单侧微量注射到Sol中的肾上腺素可使平均动脉血压和心率显著降低，且呈剂量相关性。接近半数有效剂量（ED50）的肾上腺素（0.5 nmol）的降压作用，可被微量注射到Sol中的阈剂量NPY（1 - 36）（1 pmol）和NPY Y1受体激动剂[Leu31,Pro34]NPY（2.5 pmol）显著抵消，但不能被阈剂量的NPY（13 - 36）（50 fmol）（一种选择性Y2受体激动剂）抵消。本研究为大鼠Sol中存在参与心血管调节的拮抗性NPY Y1/肾上腺素能受体相互作用提供了证据。