Yasuhara O, Kawamata T, Aimi Y, McGeer E G, McGeer P L
Kinsmen laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Neurosci Lett. 1994 Apr 25;171(1-2):73-6. doi: 10.1016/0304-3940(94)90608-4.
Senile plaques (SPs) occur profusely in brain tissue of Alzheimer disease (AD) cases, and sparsely in brain tissue of elderly normals. Two types of dystrophic neurites (DNs) have been identified in SPs. Type 1 are the classically described elongated forms. Type 2 are globular in shape. Type 1 DNs are stained immunohistochemically by antibodies to A68 protein, other forms of phosphorylated tau, and N-terminal epitopes of amyloid precursor protein (APP), as well as an antibody which preferentially recognized conjugated ubiquitin. Type 2 DNs are stained immunohistochemically by antibodies to chromogranin A and C-terminal epitopes of APP, as well as an antibody which preferentially recognizes free ubiquitin. SPs of AD cases usually contain a mixture of type 1 and type 2 DNs. However, in the neocortex of elderly normals, which have few neurofibrillary tangles and neuropil threads, the DNs in the SPs are restricted to type 2. These data suggest that SPs containing only type 2 DNs may be benign, and independent of neurofibrillary pathology.
老年斑（SPs）大量出现在阿尔茨海默病（AD）患者的脑组织中，而在正常老年人的脑组织中则很少见。在老年斑中已鉴定出两种类型的营养不良性神经突（DNs）。1型是经典描述的细长形式。2型呈球形。1型DNs可被抗A68蛋白抗体、其他形式的磷酸化tau蛋白、淀粉样前体蛋白（APP）的N端表位抗体以及一种优先识别结合泛素的抗体进行免疫组织化学染色。2型DNs可被嗜铬粒蛋白A抗体、APP的C端表位抗体以及一种优先识别游离泛素的抗体进行免疫组织化学染色。AD患者的老年斑通常包含1型和2型DNs的混合物。然而，在几乎没有神经原纤维缠结和神经毡丝的正常老年人新皮质中，老年斑中的DNs仅限于2型。这些数据表明，仅含有2型DNs的老年斑可能是良性的，且与神经原纤维病理无关。
