Reis L C, Ramalho M J, Antunes-Rodrigues J
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1990;23(12):1339-42.
The objective of the present study was to evaluate the role of the central serotonergic (5-HT) system in the modulation of drinking behavior induced by angiotensin II (Ang II) and carbachol. Male Wistar rats implanted with a delay cannula in the 3rd ventricle were injected with the 5-HT1C/5-HT2 agonist 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) (50 nmol/2 microliters) before receiving an intracerebroventricular (icv) injection of Ang II or carbachol (100 ng/2 microliters). MK-212 induced a significant reduction in the drinking response evoked by Ang II or carbachol which was more marked in the case of the cholinergic agonist. The results obtained suggest that thirst and water intake produced by angiotensinergic or cholinergic activation are modulated by the action of 5-HT, possibly at the level of the periventricular hypothalamus.
本研究的目的是评估中枢5-羟色胺能（5-HT）系统在调节血管紧张素II（Ang II）和卡巴胆碱诱导的饮水行为中的作用。在第三脑室植入延迟套管的雄性Wistar大鼠，在接受脑室内（icv）注射Ang II或卡巴胆碱（100 ng/2微升）之前，先注射5-HT1C/5-HT2激动剂6-氯-2-[1-哌嗪基]-吡嗪（MK-212）（50 nmol/2微升）。MK-212显著降低了Ang II或卡巴胆碱诱发的饮水反应，胆碱能激动剂的情况更为明显。所得结果表明，血管紧张素能或胆碱能激活产生的口渴和水摄入受5-HT作用的调节，可能是在室周下丘脑水平。
