Pedro B M, Pilowsky L S, Costa D C, Hemsley D R, Ell P J, Verhoeff N P, Kerwin R W, Gray N S
Department of Psychology, Institute of Psychiatry, London.
Psychol Med. 1994 May;24(2):423-9. doi: 10.1017/s0033291700027392.
Animal models suggest a relationship between disturbed striatal dopaminergic function and stereotyped behaviour. Several studies show increased stereotypy in schizophrenic patients compared to normal controls. We investigated the performance of 12 antipsychotic-drug-free schizophrenic patients, and 15 healthy control subjects on a neuropsychological measure of stereotypy--the two-choice guessing task--and correlated this with in vivo striatal dopamine D2 receptor binding, as measured by 123I-iodobenzamide single photon emission tomography. Patients and controls did not differ with respect to the measures of stereotypy derived from the task. However, there was a significant correlation between one of these measures (RR Information) and the degree of striatal D2 receptor binding asymmetry in the patient group only. In view of research connecting striatal and frontal lesions with stereotypy in animals and cognitive inflexibility in humans, these data could suggest a similar disturbance underlying the phenomenon in schizophrenia.
动物模型表明纹状体多巴胺能功能紊乱与刻板行为之间存在关联。多项研究显示，与正常对照组相比，精神分裂症患者的刻板行为增加。我们对12名未服用抗精神病药物的精神分裂症患者和15名健康对照者进行了一项关于刻板行为的神经心理学测量——二选一猜测任务，并将其与通过123I-碘苄胺单光子发射断层扫描测量的体内纹状体多巴胺D2受体结合情况进行关联。患者和对照在源自该任务的刻板行为测量方面没有差异。然而，仅在患者组中，这些测量指标之一（RR信息）与纹状体D2受体结合不对称程度之间存在显著相关性。鉴于有研究将动物的纹状体和额叶损伤与刻板行为以及人类的认知灵活性联系起来，这些数据可能表明精神分裂症中该现象背后存在类似的紊乱。
