Pilowsky L S, Costa D C, Ell P J, Verhoeff N P, Murray R M, Kerwin R W
Institute of Psychiatry, De Crespigny Park, London.
Br J Psychiatry. 1994 Jan;164(1):16-26. doi: 10.1192/bjp.164.1.16.
We used SPECT to examine striatal D2 receptor binding in 20 antipsychotic-free DSM-III-R schizophrenic patients and 20 age- and sex-matched normal controls. Dynamic single-slice SPECT, at a slice chosen to include the basal ganglia, began immediately following intravenous injection of 185 MBq of 123I-IBZM. A semiquantitative approach was used to generate indices of specific D2 receptor binding in the basal ganglia. There was no overall elevation of D2 receptor binding between patients and controls. A male sex-specific left lateralised asymmetry of striatal D2 receptor binding was found in the patient group. Age-dependent decline of striatal D2 receptors was confirmed in controls, but not in patients. These results suggest that alterations in striatal D2 receptor distribution and density do occur in schizophrenia, and possibly reflect wider disruptions in prefrontal-striatal-limbic circuits.
我们使用单光子发射计算机断层扫描（SPECT）检查了20名未服用抗精神病药物的DSM-III-R精神分裂症患者以及20名年龄和性别匹配的正常对照者的纹状体D2受体结合情况。在静脉注射185 MBq的123I-碘苄胍（123I-IBZM）后，立即对选定包含基底神经节的层面进行动态单层SPECT检查。采用半定量方法生成基底神经节中特定D2受体结合的指标。患者和对照者之间的D2受体结合总体上没有升高。在患者组中发现了纹状体D2受体结合的男性特异性左侧不对称。在对照组中证实了纹状体D2受体随年龄的下降，但在患者中未证实。这些结果表明，精神分裂症中确实存在纹状体D2受体分布和密度的改变，并且可能反映了前额叶-纹状体-边缘回路中更广泛的破坏。
