Unverdorben M, Birkenhake S, Kunkel B, Dunst J
Medizinische Klinik II mit Poliklinik, Universität Erlangen-Nürnberg.
Strahlenther Onkol. 1994 Aug;170(8):461-6.
We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a "hibernating myocardium" during continuous infusion of 5-FU.
In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogenic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.
我们报告了一名患有肛门癌的年轻女性患者，她接受了同步放化疗，在持续输注5-氟尿嘧啶期间出现了“冬眠心肌”。
文献中发现5-氟尿嘧啶治疗引起的心脏并发症发生率在1%至10%之间。冠心病患者的风险高出四倍。可能的致病机制是冠状动脉痉挛、直接心脏毒性、免疫反应和凝血系统紊乱。
